COLLAGENASE (kohl LAH jen ace) is used to treat Dupuytren's contracture. This medicine may help straighten a bent finger by breaking up hard tissue. It is also used for Peyronie's disease by breaking up the hard tissue plaque that causes the curvature in the penis.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
They need to know if you have any of these conditions:
low platelet counts
take medicines that treat or prevent blood clots
an unusual or allergic reaction to collagenase, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
This medicine is for injection into the hand or penis. It is given by a health care professional in a hospital or clinic setting.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.
aspirin and aspirin-like medicines
certain medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Your condition will be monitored carefully while you are receiving this medicine.
If being treated for Dupuytren's contracture, return to your healthcare provider the day after your hand is injected. In the meantime, do not flex or extend the fingers of your hand that was injected. Do not touch your finger that was injected, and elevate your hand until bedtime. Do not perform activity with the injected hand until you are told that it is OK. Follow any instructions about wearing a splint or performing finger exercises. Also, call your healthcare provider if you get increasing redness or swelling in the hand, if you have numbness or tingling in the treated finger, or if you have trouble bending the finger after the swelling goes down.
If being treated for Peyronie's disease, you will need to return to your healthcare provider for a manual procedure that will stretch and help straighten your penis. Also, your healthcare provider will show you how to gently stretch your penis at home. Do not resume sexual activity until you are told that it is okay. Follow instructions on when to return for follow-up visits. Immediately call your doctor if you have trouble stretching or straightening your penis, or if you have pain or other concerns.
Immediately call your healthcare provider if you get a fever or chills.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
chest pain or palpitations
pain in your penis
pain when urinating
red or dark-brown urine
sudden loss of the ability to maintain an erection
swelling of the injected hand
unusual swelling or bruising of the penis
Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):
irritation at site where injected
pain at site where injected
unusual bleeding or bruising
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
This drug is given in a hospital or clinic and will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
COLLAGENASE (kohl LAH jen ace) is an enzyme that breaks down collagen in damaged tissue and helps healthy tissue to grow. It may help wounds heal faster.
This medicine is for external use only. Do not take by mouth. Wash the wound as directed by your health care professional. Do not scrub. If you are applying a topical antibiotic to the wound, apply the antibiotic before this medicine. Do not touch the tip of the ointment tube with any surface, especially your fingers or the wound. Try to only get the ointment on the wound itself. If some gets on normal skin, wipe away with a sterile gauze pad. Do not use your medicine more often than directed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.
Do not take this medicine with any of the following medications:
aluminum acetate, Burow's solution
Visit your doctor or health care professional for regular checks on your progress. If your wound begins to look worse, smell bad, has colored discharge or more discharge, or increases in size, contact your health care professional. You may have an infection or need a change in your treatment.
If you develop a fever, chills, low blood pressure, dizziness, rapid heartbeat, or confusion, contact your health care professional immediately. You may have an infection of your blood.
skin rash or hives
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
redness at the application site
Keep out of the reach of children.
Store below 25 degrees C (77 degrees F). Throw away any unused medication after the expiration date.