REGULAR INSULIN: ISOPHANE INSULIN (REG yuh ler IN su lin;ISO fane IN su lin) is a human-made form of insulin. This medicine lowers the amount of sugar in your blood. It is a combination insulin that starts working about 30 minutes after it is injected and works for as long as 12 to 24 hours.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
They need to know if you have any of these conditions:
episodes of hypoglycemia
an unusual or allergic reaction to insulin, metacresol, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
This medicine is for injection under the skin. Use exactly as directed. It is important to follow the directions given to you by your doctor or health care professional. Your doctor or health care professional will tell you how long to wait after you inject your dose before eating a meal. Most of the time, you should wait about 30 minutes. You will be taught how to use this medicine and how to adjust doses for activities and illness. Do not use more insulin than prescribed. Do not use more or less often than prescribed.
Always check the appearance of your insulin before using it. This medicine should be white and cloudy before mixing and uniformly cloudy after mixing. To mix, roll the vial gently 10 times in your hands. Do not use it if it is colored, if it has solid particles in it, or if it does not mix.
It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
It is important not to miss a dose. Your health care professional or doctor should discuss a plan for missed doses with you. If you do miss a dose, follow their plan. Do not take double doses.
other medicines for diabetes
Many medications may cause an increase or decrease in blood sugar, these include:
alcohol containing beverages
aspirin and aspirin-like drugs
female hormones, like estrogens or progestins and birth control pills
MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
male hormones or anabolic steroids
medicines for weight loss
medicines for allergies, asthma, cold, or cough
medicines for mental problems
NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
quinolone antibiotics like ciprofloxacin, levofloxacin, ofloxacin
some herbal dietary supplements
steroid medicines like prednisone or cortisone
Some medications can hide the warning symptoms of low blood sugar. You may need to monitor your blood sugar more closely if you are taking one of these medications. These include:
beta-blockers such as atenolol, metoprolol, propranolol
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Visit your health care professional or doctor for regular checks on your progress.
A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.
Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.
Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.
Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.
Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. Many nonprescription cough and cold products contain sugar or alcohol. These can affect blood sugar.
Make sure that you have the right kind of syringe for the type of insulin you use. Try not to change the brand and type of insulin or syringe unless your health care professional or doctor tells you to. Switching insulin brand or type can cause dangerously high or low blood sugar. Always keep an extra supply of insulin, syringes, and needles on hand. Use a syringe one time only. Throw away syringe and needle in a closed container to prevent accidental needle sticks.
Insulin pens and cartridges should never be shared. Sharing may result in passing of viruses like hepatitis or HIV.
Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.
Side effects that you should report to your health care professional or doctor as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
signs and symptoms of high blood sugar such as dizziness, dry mouth, dry skin, fruity breath, nausea, stomach pain, increased hunger or thirst, increased urination
signs and symptoms of low blood sugar such as feeling anxious, confusion, dizziness, increased hunger, unusually weak or tired, sweating, shakiness, cold, irritable, headache, blurred vision, fast heartbeat, loss of consciousness
Side effects that usually do not require medical attention (report to your health care professional or doctor if they continue or are bothersome):
increase or decrease in fatty tissue under the skin due to overuse of a particular injection site
itching, burning, swelling, or rash at site where injected
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children.
Store unopened insulin vials in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Do not freeze or use if the insulin has been frozen. Opened vials (vials currently in use) may be stored in the refrigerator or at room temperature, at approximately 30 degrees C (86 degrees F) or cooler. Keeping your insulin at room temperature decreases the amount of pain during injection. If you are using Humulin brand 70/30 vials, your insulin can be used until the expiration date printed on the vial. If you are using Novolin brand 70/30 vials, your insulin should be thrown away after 42 days.
Store unopened pre-filled pens in a refrigerator between 2 to 8 degrees C (36 to 46 degrees F). Do not freeze or use if the insulin has been frozen. After opening, keep this medicine at room temperature, approximately 25 degrees C (77 degrees F) or cooler. Do not store in the refrigerator. Once opened, the insulin can be used for 10 days. After 10 days, the insulin pen should be thrown away.
Protect from light and excessive heat. Throw away any unused medicine after the expiration date or after the specified time for room temperature storage has passed.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.