ISONIAZID; PYRAZINAMIDE; RIFAMPIN (eye soe NYE a zid; peer a ZIN a mide; RIF am pin) is a combination of three antibiotics. It is used to treat tuberculosis (TB). It will not work for colds, flu, or other viral infections.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
They need to know if you have any of these conditions:
if you frequently drink alcohol-containing beverages
tingling of the fingers or toes, or other nerve disorder
an unusual or allergic reaction to isoniazid, rifampin, rifabutin, pyrazinamide, other medicines, foods, dyes or preservatives
pregnant or trying to get pregnant
Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, either 1 hour before or 2 hours after food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early. Skipping doses may make the TB resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 15 years for selected conditions, precautions do apply.
Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Do not take this medicine with any of the following medications:
certain antiviral medicines for HIV or AIDS
MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
This medicine may also interact with the following medications:
barbiturates like phenobarbital
beta-blockers like metoprolol and propranolol
calcium channel blockers like diltiazem, nifedipine and verapamil
certain antibiotics like ciprofloxacin
certain medicines for depression, anxiety, or psychotic disturbances
certain medicines for diabetes, like glipizide or glyburide
certain medicines for fungal infections like fluconazole, ketoconazole and itraconazole
certain medicines for irregular heart beat like disopyramide, mexiletine, quinidine
certain medicines for seizures like carbamazepine, phenobarbital, phenytoin, valproic acid
certain medicines for sleep
certain medicines that treat or prevent blood clots like warfarin
female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
narcotic medicines for pain
steroid medicines like prednisone or cortisone
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Visit your doctor or health care professional for regular checks on your progress. You will need blood work done regularly.
You may need to take vitamin supplements while on this medicine. Talk to your doctor about the foods you eat and the vitamins you take. Avoid taking antacids containing aluminum, calcium or magnesium, and iron-containing products within 2 hours of taking this medicine. It is best to separate these medicines by 4 to 6 hours.
If you are diabetic, monitor your blood sugars closely. This medicine may change the way your diabetic medicine works, and sometimes will require that your dosages be adjusted. Check with your doctor or health care professional.
If you have diabetes, you may get a false-positive result for sugar in your urine. Check with your doctor or health care professional.
This medicine can cause serious liver problems. Make sure you understand the risks for liver problems and how to identify the symptoms. If you have any questions, talk with your doctor or other health care provider.
Avoid alcoholic drinks while you are taking this medicine. Drinking alcohol during treatment with this medicine increases the risk of serious liver problems.
Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.
This medicine can color your urine, feces (stool), perspiration (sweat), tears, sputum, skin or saliva reddish-orange to reddish-brown. This color can last for as long as you take this medicine and is not a cause for alarm. This color in tears may permanently stain soft contact lenses. It is better not to wear soft contact lenses while you are taking this medicine.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
You may get a false-positive result for sugar in your urine while you are taking this medicine. Talk with your doctor.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
changes in vision or eye pain
chest pain or chest tightness
fast, irregular heartbeat
feeling faint or lightheaded, falls
fever or chills
hallucination, loss of contact with reality
pain, tingling, numbness in the hands or feet
pinpoint red spots on the skin
redness, blistering, peeling or loosening of the skin, including inside the mouth
ringing of the ears
symptoms of gout
trouble passing urine or change in the amount of urine
unusual bleeding, bruising
unusually weak or tired
yellowing of the eyes or skin
Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):
breast enlargement or tenderness
general ill feeling or flu-like symptoms
loss of appetite
swelling of the ankles, feet, hands
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.