AxitinibAxitinib

Axitinib Oral tablet

What is this medicine?

AXITINIB (ax I ti nib) is a chemotherapy drug. It targets a specific protein within cancer cells and stops the cancer cells from growing. It is used to treat kidney cancers.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • bleeding disorders

  • brain tumor

  • high blood pressure

  • history of blood clots

  • liver disease

  • stomach problems

  • thyroid disease

  • an unusual or allergic reaction to axitinib, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Do not cut, crush, or chew this medicine. Do not take with grapefruit juice. You can take this medicine with or without food. If it upsets your stomach, take it with food. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose and skip your missed dose. Do not take double or extra doses.

What may interact with this medicine?

This medicine may interact with the following medications:

  • antiviral medicines for HIV or AIDS like atazanavir, efavirenz, etravirine, indinavir, nelfinavir, ritonavir, saquinavir

  • bosentan

  • clarithromycin

  • dexamethasone

  • grapefruit or grapefruit juice

  • medicines for fungal infections like ketoconazole, itraconazole, voriconazole

  • medicines for seizures like carbamazepine, phenobarbital, phenytoin

  • modafinil

  • nafcillin

  • nefazodone

  • rifabutin

  • rifampin

  • rifapentin

  • St. John's wort

  • telithromycin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor for checks on your progress. Report any new symptoms promptly.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Men should inform their doctors

if they wish to father a child. This medicine may lower sperm counts. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • black, tarry stools

  • breathing problems

  • changes in vision

  • chest pain or chest tightness

  • confusion, trouble speaking or understanding

  • high blood pressure

  • red or dark-brown urine

  • red spots on the skin

  • seizures

  • severe headaches

  • spitting up blood or brown material that looks like coffee grounds

  • stomach pain

  • sudden numbness or weakness of the face, arm or leg

  • swelling in a leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual bruising or bleeding from the eye, gums, or nose

Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):

  • constipation

  • cough

  • diarrhea

  • loss of appetite

  • nausea, vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store tablets at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.


 

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