BosutinibBosutinib

Bosutinib Oral tablet

What is this medicine?

BOSUTINIB (boe SUE ti nib) is a chemotherapy drug. It targets specific proteins within cancer cells and stops the cancer cell from growing. This medicine is used to treat chronic myelogenous leukemia.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • heart disease

  • kidney disease

  • liver disease

  • an unusual or allergic reaction to bosutinib, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Do not cut, crush, or chew this medicine. Do not take with grapefruit juice. Avoid taking H2 blockers or antacids within 2 hours of taking this medicine. It is best to separate these medicines by 2 hours. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 12 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.

What may interact with this medicine?

This medicine may interact with the following:

  • amprenavir

  • antacids

  • aprepitant

  • atazanavir

  • boceprevir

  • bosentan

  • certain medications for fungal infections like fluconazole, ketoconazole, itraconazole, posaconazole, and voriconazole

  • certain medications for seizures like carbamazepine, phenobarbital, and phenytoin

  • certain medications for stomach problems like cimetidine, famotidine, ranitidine, esomeprazole, dexlansoprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole

  • ciprofloxacin

  • clarithromycin

  • conivaptan

  • crizotinib

  • darunavir

  • digoxin

  • diltiazem

  • efavirenz

  • erythromycin

  • etravirine

  • fosamprevir

  • grapefruit juice

  • imatinib

  • indinavir

  • modafinil

  • nafcillin

  • nefazodone

  • nelfinavir

  • rifabutin

  • rifampin

  • ritonavir

  • saquinavir

  • St. John’s Wort

  • telaprevir

  • telithromycin

  • verapamil

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

You may need blood work done while you are taking this medicine.

Do not become pregnant while taking this medicine or for 30 days after it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • chest pain or chest tightness

  • cough

  • dark urine

  • diarrhea

  • dizziness

  • headache

  • joint pain

  • loss of appetite

  • low blood counts

  • nausea, vomiting

  • red or dark brown urine

  • signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine

  • signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine

  • stomach pain

  • swelling of the ankles, feet, hands

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):

  • rash

  • unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.


 

Bayhealth is Southern Delaware’s healthcare leader with hospitals in Dover and in Milford. Bayhealth provides a wide range of medical services, including cardiovascular, cancer, orthopaedics and rehabilitation, pediatrics, respiratory care, sleep care, surgical weight loss, women’s services and walk-in medical care. Search for nursing jobs, and health classes and events. Find doctors affiliated with Bayhealth Medical Center or a Delaware hospital near you.