RMSF, Rocky Mountain spotted fever antibodies
Rocky Mountain spotted fever serum is a blood test used to look for antibodies, or proteins, that the body makes to fight Rocky Mountain spotted fever (RMSF) infections. RMSF is a serious bacterial infection caused by a bite from an infected tick. In most people, antibodies can't be detected until at least a week after infection.
A blood sample is taken about a week after symptoms appear and again two to four weeks later.
You may need this test to confirm a diagnosis of RMSF and to evaluate the effectiveness of treatment. Symptoms of RMSF include:
Your doctor might order other blood tests, including a complete blood cell count, or CBC, and a chemistry panel. A low platelet count, low sodium level, or elevated liver enzymes could indicate RMSF. If you have a skin rash, your doctor may order a skin biopsy to look for bacterial infection in the cells that line your blood vessels.
Many things may affect your lab test results. These include the method each lab uses to do the test. Even if your test results are different from the normal value, you may not have a problem. To learn what the results mean for you, talk with your health care provider.
If your initial test results are negative, it's still possible you are infected. It's critical to start treatment right away, so your doctor may suggest treatment even if your results are negative and then repeat the test in a week or two.
Doctors look for a rise in the antibodies. If the second test shows a significant rise in antibodies, it can confirm that you have RMSF.
The antibodies may stay elevated for months or even years after infection.
The test requires a blood sample, which is drawn through a needle from a vein in your arm.
Taking a blood sample with a needle carries risks that include bleeding, infection, bruising, or feeling dizzy. When the needle pricks your arm, you may feel a slight stinging sensation or pain. Afterward, the site may be slightly sore.
Antigens may be present in your blood if you have been exposed to related organisms. Antibiotic treatment also can affect your test results.
You don't need to prepare for this test.