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DARUNAVIR (da ROON a veer) is an antiretroviral medicine. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. It will not stop the spread of HIV to others.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
They need to know if you have any of these conditions:
an unusual or allergic reaction to darunavir, sulfa medicines, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Take this medicine by mouth. Follow the directions on the prescription label. Shake well before using. Take this medicine with food. Use a specially marked spoon or dropper to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 3 years for selected conditions, precautions do apply.
Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, take it as soon as you can. If you usually take your medicine once a day and your next dose is to be taken in less than 12 hours, then do not take the missed dose. If you usually take your medicine twice a day and your next dose is to be taken in less than 6 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.
Do not take this medicine with any of the following medications:
colchicine (if you have liver or kidney problems)
medicines for cholesterol like lovastatin, simvastatin
medicines for headaches like dihydroergotamine, ergonovine, ergotamine, methylergonovine
red yeast rice
salmeterol or fluticasone; salmeterol
sildenafil (for the treatment of pulmonary arterial hypertension)
St. John's wort
This medicine may also interact with the following medications:
certain antibiotics like clarithromycin, rifabutin, rifapentine
certain other antiviral medicines for HIV like didanosine, indinavir, maraviroc, saquinavir, or lopinavir; ritonavir
certain medicines for anxiety or sleep like buspirone, diazepam, zolpidem
certain medicines for blood pressure and heart disease like amlodipine, carvedilol, diltiazem, felodipine, metoprolol, nicardipine, nifedipine, timolol, verapamil
certain medicines for cancer like dasatinib, nilotinib, vinblastine, vincristine
certain medicines for depression like amitriptyline, desipramine, imipramine, nortriptyline, paroxetine, sertraline, and trazodone
certain medicines for erectile dysfunction like avanafil, sildenafil, tadalafil, vardenafil
certain medicines for fungal infection like itraconazole, ketoconazole, posaconazole, voriconazole
certain medicines for hepatitis infection like boceprevir, simeprevir, telaprevir
certain medicines for psychotic disturbances like quetiapine, risperidone, thioridazine
certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
certain medicines that treat or prevent blood clots likes apixaban, dabigatran, rivaroxaban, warfarin
female hormones, like estrogens and progestins and birth control pills
medicines for cholesterol like atorvastatin, pravastatin, rosuvastatin
medicines for irregular heart beat like amiodarone, bepridil, digoxin, disopyramide, flecainide, lidocaine, mexiletine, propafenone, quinidine
medicines that lower your chance of fighting infection like cyclosporine, everolimus, sirolimus, tacrolimus
narcotic medicines for pain such as buprenorphine, buprenorphine; naloxone, methadone
steroid medicines like budesonide, dexamethasone, fluticasone, prednisolone
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.
HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.
Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control. Women who can still have children must use a reliable form of barrier contraception, like a condom or diaphragm.
This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
increased hunger or thirst
loss of appetite
pain in the lower back or side
pain when urinating
pain, tingling, numbness in the hands or feet
redness, blistering, peeling or loosening of the skin, including inside the mouth
right upper belly pain
trouble passing urine or change in the amount of urine
unusually weak or tired
yellowing of the eyes or skin
Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):
weight gain around waist, back, or thinning of face, arms, legs
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
Bayhealth is Southern Delaware’s healthcare leader with hospitals in Dover and in Milford. Bayhealth provides a wide range of medical services, including cardiovascular, cancer, orthopaedics and rehabilitation, pediatrics, respiratory care, sleep care, surgical weight loss and women’s services.