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Acne is a disorder of the hair follicles and sebaceous glands. With acne, the sebaceous glands are clogged. This leads to pimples and cysts.
Acne is very common. Nearly 80% of individuals in the U.S. between 11 and 30 years old will be affected by this condition at some point. Acne most often begins in puberty. During puberty, the male sex hormones (androgens) increase in both boys and girls, causing the sebaceous glands to become more active. This results in increased production of sebum. While acne is most common during puberty it can happen at any age. About 20% of males over 25 and 40% of females over 25 suffer from acne.
The sebaceous glands make oil (sebum) which normally travels via hair follicles to the skin surface. However, skin cells can plug the follicles. This blocks the oil coming from the sebaceous glands. When follicles become plugged, skin bacteria (called Propionibacterium acnes, or P. acnes) begin to grow inside the follicles, causing inflammation. Acne progresses in the following manner:
Incomplete blockage of the hair follicle results in blackheads (a semisolid, black plug).
Complete blockage of the hair follicle results in whiteheads (a semisolid, white plug).
Infection and irritation cause whiteheads to form.
Eventually, the plugged follicle bursts, spilling oil, skin cells, and the bacteria onto the skin surface. In turn, the skin becomes irritated. Pimples or lesions begin to develop. The basic acne lesion is called a comedo.
Acne can be superficial papules or pustules. These are pimples without abscesses. Or deep nodules or cysts. This is when the inflamed pimples push down into the skin, causing pus-filled cysts that rupture and result in larger abscesses).
Rising hormone levels during puberty may cause acne. In addition, acne is often inherited or genetic. Other causes of acne may include the following:
Hormone level changes during the menstrual cycle in women, hormone changes during pregnancy or changes when women start or stop birth control.
Certain drugs (like corticosteroids)
Oil and grease from the scalp, mineral or cooking oil, oil, hair spray, and certain cosmetics may worsen acne
Bacteria inside pimples
Tight clothes that rub or cause irritation may cause acne on the body.
Diet with sugar possibly related to acne development. May help to switch to low-sugar diets.
Obesity has been associated with increased acne risk.
If a close family member had acne, other family members are at increased risk.
Acne and scarring can be aggravated by squeezing the pimples or by scrubbing the skin too hard.
Acne can happen anywhere on the body. However, acne most often appears in areas where there is a high concentration of sebaceous glands, including the following:
The following are the most common symptoms of acne. However, each child may experience symptoms differently. Symptoms may include:
Pus-filled lesions that may be painful
Nodules (solid, raised bumps)
The symptoms of acne may look like other skin conditions. Always talk with your child's health care provider for a diagnosis.
Specific treatment will be decided by your child's health care provider based on:
Your child's age, overall health, and medical history
Severity of the acne
Your child's tolerance for specific medicines, procedures, or therapies
Expectations for the course of the condition
Your opinion or preference
The goal of acne treatment is to minimize scarring and improve appearance. Treatment for acne will include topical or systemic drug therapy. Many effective over-the-counter topical medicines are available. When buying lotions or makeup, effort should be made to find products labeled "noncomedogenic or nonacnegenic," since these products do not clog pores. Depending on the severity of acne, topical medicines (medicines applied to the skin) or systemic medicines (medicines taken orally) may be prescribed by your child's health care provider. In some cases, a combination of both topical and systemic medicines may be recommended.
Topical medicines are often prescribed to treat acne. Topical medicine can be in the form of a cream, gel, lotion, or solution. Examples include:
Kills the bacteria (P. acnes)
Helps stop or slow down the growth of P. acnes and reduces inflammation (clindamycin, dapsone, and erythromycin are examples)
Stops the development of new acne lesions (comedones) and encourages cell turnover, unplugging pimples
Decreases comedo formation
Normalizes keratinocyte production and has anti-inflammatory effects
Similar to tretinoin in the way it works
Systemic antibiotics are often prescribed to treat moderate to severe acne, and may include the following:
Isotretinoin, an oral drug, may be prescribed for individuals with severe, cystic, or inflammatory acne that cannot be effectively treated by other methods to prevent extensive scarring. Isotretinoin reduces the size of the sebaceous glands that produce the skin oil. It increases skin cell shedding, and affects the hair follicles, thereby reducing the development of acne lesions. Isotretinoin can clear acne in 85% of patients. However, the drug has major unwanted side effects, including psychiatric side effects. It is very important to discuss this prescription medicine with your child's health care provider.
Isotretinoin must not be taken by women who are pregnant or who are able to become pregnant. There is a very high likelihood of birth defects happening in babies whose mothers took the medicine during pregnancy. Isotretinoin can also cause miscarriage or premature birth. Because of these effects and to minimize fetal exposure, isotretinoin is approved for marketing only under a special restricted distribution program approved by the FDA. This program is called iPLEDGE.
The goal of the iPLEDGE program is to prevent pregnancies in females taking isotretinoin and to prevent pregnant females from taking isotretinoin. Requirements of the iPLEDGE program include:
Isotretinoin must only be prescribed by prescribers who are registered and activated with the iPLEDGE program.
Isotretinoin must only be dispensed by a pharmacy registered and activated with iPLEDGE.
Isotretinoin must only be dispensed to patients who are registered with and meet all the requirements of iPLEDGE
Female patients who can get pregnant are required to use 2 methods of birth control for 1 month prior to treatment, during treatment, and for 1 month after stopping treatment.
Pregnancy tests are required before, during, and after treatment.
Bayhealth is Southern Delaware’s healthcare leader with hospitals in Dover and in Milford. Bayhealth provides a wide range of medical services, including cardiovascular, cancer, orthopaedics and rehabilitation, pediatrics, respiratory care, sleep care, surgical weight loss and women’s services.