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Cobalamin, Cbl, folic acid, FA
This test measures the levels of vitamin B-12 and folate in your blood.
Your body needs vitamin B-12, also called cobalamin, and folate, also called folic acid, to function normally. Both nutrients play important roles in creating red blood cells and making DNA and RNA to help build cells. B-12 also helps your nervous system function as it should.
B-12 is found in fortified cereals and animal products like fish, meat, eggs, and dairy. It's also in dietary supplements, as cyanocobalamin. Folate is found naturally in green leafy vegetables, fruits, and beans. It's also added to enriched cereals and grains.
People who have pernicious anemia may have low B-12 levels because this condition prevents them from absorbing B-12. A low folate level can also be the result of a poor diet or alcohol abuse.
You may have this test if you are taking medicines that could interfere with how your body absorbs B-12 or folate. You may also have this test if you have a disease or condition that could lead to B-12 deficiency. Symptoms of B-12 deficiency include:
Numbness or "pins and needles" in the hands and feet
Difficulty thinking normally
Changes in mood
Symptoms of having too little folate are diarrhea, weight loss, and other vague symptoms that could be caused by many other conditions.
It's important that women who are pregnant, thinking of becoming pregnant, or breastfeeding have enough folate.
This test measures both vitamin B-12 and folate, but either of these nutrients can be measured separately in different lab tests. Your healthcare provider may order this combined test if you have a condition for which it's important to know both levels.
Your healthcare provider may also order these tests:
Homocysteine and methylmalonate, or methylmalonic acid. These substances can build up in your body if you have a B-12 or folate deficiency.
Red blood cell
Pernicious anemia. This includes measuring levels of gastrin, pepsinogen I, pepsinogen II, and antibodies against a substance called intrinsic factor.
Many things may affect your lab test results. These include the method each lab uses to do the test. Even if your test results are different from the normal value, you may not have a problem. To learn what the results mean for you, talk with your healthcare provider.
Results are given in nanograms per milliliter (ng/mL). A normal range for vitamin B-12 is 190 to 900 ng/mL.
If your B-12 results are low, it may mean you have:
Stomach issues, such as lack of stomach acid, that make it difficult to absorb the vitamin
Your diet can also lead to B-12 deficiency. Some vegetarians or vegans who don't eat eggs or other dairy products may develop this deficiency.
Your B-12 results may also be higher or lower if you have had recent nuclear medicine studies using radiation. They can mean that you have:
Severe liver disease
Chronic granulocytic leukemia
If the test is done on your blood plasma, a normal range for folate is 2 to 10 ng/mL. If the test is done on red blood cells, a normal range is 140 to 960 ng/mL.
If your folate results are low, it may mean you have:
A diet that doesn't provide enough folate
Difficulty absorbing the nutrient
The test requires a blood sample, which is drawn through a needle from a vein in your arm.
Taking a blood sample with a needle carries risks that include bleeding, infection, bruising, or feeling dizzy. When the needle pricks your arm, you may feel a slight stinging sensation or pain. Afterward, the site may be slightly sore.
Being pregnant can affect your results, as can eating foods that are high or low in folate. Alcohol use can also affect your results. Certain medicines can also affect your results. These include:
Birth control pills
Tell your healthcare provider about health conditions you have, and how much alcohol you drink regularly. In addition, be sure your provider knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illicit drugs you may use.
Bayhealth is Southern Delaware’s healthcare leader with hospitals in Dover and in Milford. Bayhealth provides a wide range of medical services, including cardiovascular, cancer, orthopaedics and rehabilitation, pediatrics, respiratory care, sleep care, surgical weight loss and women’s services.