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Thrombocythemia, also called primary or essential thrombocythemia, is a myeloproliferative disorder (a type of disease in which the bone marrow makes too many red blood cells, white blood cells, or platelets). It is characterized by the production of too many platelets in the bone marrow. Too many platelets make normal clotting of blood difficult. This can result in too much clotting, or not enough clotting.
There may be no single cause for thrombocythemia. It is believed to be caused by mutations to megakaryocytes, the platelet-making cells in the bone marrow.
The following are the most common symptoms of thrombocythemia. However, each individual may experience symptoms differently. Symptoms may include:
Blood clots in arteries and veins, commonly in the hands, feet, and brain
Bleeding from the nose, gums, and gastrointestinal tract
Hemorrhaging after injury or surgery
Headache and dizziness
Enlarged lymph nodes
The symptoms of thrombocythemia may resemble other blood disorders or medical problems. Always consult your doctor for a diagnosis.
In addition to a complete medical history and physical examination, diagnostic procedures for thrombocythemia may include blood tests to measure blood counts, and a blood smear to further assess your platelets. Excluding other causes of reactive thrombocytosis as well as other myeloproliferative disorders is important in the workup. Bone marrow biopsy (the marrow may be removed by aspiration or a needle biopsy under local anesthesia) may also be necessary.
Specific treatment for thrombocythemia will be determined by your doctor based on:
Your age, overall health, and medical history
Extent of the disease
Your tolerance for specific medications, procedures, or therapies
Expectations for the course of the disease
Your opinion or preference
Treatment may include:
Chemotherapy. This is most often administered with hydroxyurea, an oral chemotherapy drug, or interferon alpha.
Plateletpheresis. This is a procedure to remove extra platelets from the blood.
Bayhealth is Southern Delaware’s healthcare leader with hospitals in Dover and in Milford. Bayhealth provides a wide range of medical services, including cardiovascular, cancer, orthopaedics and rehabilitation, pediatrics, respiratory care, sleep care, surgical weight loss and women’s services.