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Avascular NecrosisNecrosis Avascular

Avascular Necrosis

What is avascular necrosis?

Avascular necrosis is a disease that results from the temporary or permanent loss of blood supply to the bone. When blood supply is cut off, the bone tissue dies and the bone collapses. If avascular necrosis occurs near a joint, the joint surface may collapse.

This condition may occur in any bone. It most commonly occurs in the ends of a long bone. It may affect one bone, several bones at one time, or different bones at different times.

What causes avascular necrosis?

Avascular necrosis may be the result of the following:

  • Injury
  • Fracture
  • Damage to blood vessels
  • Long-term use of medications, such as corticosteroids
  • Excessive, long-term use of alcohol

What are the risk factors for avascular necrosis?

Risk factors include:

  • Injury
  • Steroid use
  • Gaucher disease
  • Alcohol use
  • Blood disorders, such as sickle cell anemia
  • Radiation treatments
  • Chemotherapy
  • Pancreatitis
  • Decompression disease

What are the symptoms of avascular necrosis?

The following are the most common symptoms of avascular necrosis. However, each person may experience symptoms differently. Symptoms may include:

  • Minimal early joint pain
  • Increased joint pain as bone and joint begin to collapse
  • Limited range of motion due to pain

The symptoms of avascular necrosis may look like other medical conditions or bone problems. Always consult your doctor for a diagnosis.

How is avascular necrosis diagnosed?

Along with a complete medical history and physical exam, you may have one or more of the following tests:

  • X-ray. This test uses invisible electromagnetic energy beams to make images of internal tissues, bones, and organs onto film.
  • Computed tomography scan (also called a CT or CAT scan). This procedure uses a combination of X-rays and computer technology to produce horizontal, or axial, images (often called slices) of the body. A CT scan shows detailed images of any part of the body, including the bones, muscles, fat, and organs. CT scans are more detailed than general X-rays.
  • Magnetic resonance imaging (MRI).  This test uses large magnets, radiofrequencies, and a computer to make detailed images of organs and structures within the body.
  • Radionuclide bone scan. This nuclear imaging technique uses a very small amount of radioactive material, which is injected into the blood to be detected by a scanner. This test shows blood flow to the bone and cell activity within the bone.
  • Biopsy. A procedure in which tissue samples are removed (with a needle or during surgery) from the body for exam under a microscope. It’s done to find cancer or other abnormal cells or remove tissue from the affected bone.
  • Functional evaluation of bone. Tests that usually involve surgery to measure the pressure inside the bone.

How is avascular necrosis treated?

Specific treatment for avascular necrosis will be determined by your doctor based on:

  • Your age, overall health, and medical history
  • Extent of the disease
  • Location and amount of bone affected
  • Underlying cause of the disease
  • Your tolerance for specific medications, procedures, or therapies
  • Expectations for the course of the disease
  • Your opinion or preference

The goal of treatment is to improve functionality and stop further damage to the bone or joint. Treatments are needed to keep joints from breaking down, and may include:

  • Medications. These are used to control pain.
  • Assistive devices. These are used to reduce weight on the bone or joint.
  • Core decompression. For this surgical procedure, the inner layer of bone is removed to reduce pressure, increase blood flow, and slow or stop bone and/or joint destruction.
  • Osteotomy. This procedure reshapes the bone and reduces stress on the affected area.
  • Bone graft. In this procedure, healthy bone is transplanted from another part of the body into the affected area.
  • Joint replacement. This surgical procedure removes and replaces an arthritic or damaged joint with an artificial joint. This may be considered only after other treatment options have failed to relieve from pain and/or disability.

Other treatments may include electrical stimulation and combination therapies to promote bone growth.

Key points

  • Avascular necrosis is a disease that results from the temporary or permanent loss of blood supply to the bone. It occurs most commonly in the ends of a long bone.
  • Avascular necrosis may be the result of injury, use of medications, or alcohol.  
  • Symptoms may include joint pain and limited range of motion.
  • Medications, assistive devices or surgery may be used to improve functionality or to stop further damage to the affected bone or joint.

Next steps

Tips to help you get the most from a visit to your health care provider:

  • Before your visit, write down questions you want answered.
  • Bring someone with you to help you ask questions and remember what your provider tells you.
  • At the visit, write down the names of new medicines, treatments, or tests, and any new instructions your provider gives you.
  • If you have a follow-up appointment, write down the date, time, and purpose for that visit.
  • Know how you can contact your provider if you have questions.