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Prothrombin time/PT, Pro time, Prothrombin time/International normalized ratio, PT/INR
The prothrombin time is one of several tests that evaluate whether your blood is clotting properly. Blood clotting, or coagulation, is needed to help stop bleeding. Proteins in the blood called clotting factors or coagulants help blood become sticky and clot. They change it from a liquid to a solid.
As soon as you get a cut or the body starts to bleed, platelet cells in the blood collect around the bleeding area. The platelet cells and clotting factors then react to thicken the blood and stop the bleeding. Abnormalities in the blood, including deficiencies in clotting factors or platelets, can keep blood from clotting normally and cause abnormal bleeding.
Clotting factors are usually made by the liver. Prothrombin is one type of clotting factor. When bleeding occurs somewhere in the body, prothrombin quickly changes to thrombin. The prothrombin time test measures how quickly prothrombin changes to thrombin to stop the bleeding. If the prothrombin doesn't change as quickly as normal, a blood clotting disorder could be the cause.
The prothrombin time test can find a lack of certain coagulants if the blood does not clot normally. The prothrombin time test may be used to help diagnose inherited disorders and other conditions that may affect blood clotting. These include:
Vitamin K deficiency
Deficiency in clotting factor I, II, V, VII, or X
Diseases of the liver
Problems with the bone marrow
Von Willebrand disease
Problems with the immune system
Some types of cancer, including leukemia
Your healthcare provider may order this test if you show symptoms of having a bleeding disorder. These symptoms can include:
Abnormal menstrual periods in women
Bleeding that occurs more easily
Bruising that occurs more easily
Blood in the stool
Your healthcare provider may also order this test regularly if you are taking a blood thinner such as warfarin to help make sure you are getting the right dose.
You may also need this test before you have surgery or an invasive procedure to help make sure your blood is clotting properly.
Depending on why you are having the test, your healthcare provider may order other blood tests along with the prothrombin time. These may include:
Thrombin time, or TT, test
Activated partial thromboplastin time, or aPTT
These tests also measure the ability of the blood to clot normally. Other tests that measure different aspects of blood clotting, such as platelet function, may also be done.
Many things may affect your lab test results. These include the method each lab uses to do the test. Even if your test results are different from the normal value, you may not have a problem. To learn what the results mean for you, talk with your healthcare provider.
This test result is often reported in seconds. The normal clotting time is typically between 10 and 12 seconds. If your blood does not clot within that normal range, you may have a clotting or bleeding disorder.
If this test is done because you are taking an anticoagulant such as warfarin, the result is often reported as an International Normalized Ratio, which is simply a number. Healthcare providers usually want the INR to be between 2.0 and 3.0 for people taking these drugs.
The test requires a blood sample, which is drawn through a needle from a vein in your arm.
Taking a blood sample with a needle carries risks that include bleeding, infection, bruising, or feeling dizzy. When the needle pricks your arm, you may feel a slight stinging sensation or pain. Afterward, the site may be slightly sore.
A number of medicines can affect the test results. These include medicines that are used to help prevent blood clots, such as warfarin, aspirin, direct thrombin inhibitors, factor Xa inhibitors, and heparin. Other medicines that may affect the results include:
If your blood sample is not collected correctly, your test results may also be affected.
You don't usually need to prepare for this test. Your healthcare provider will tell you whether you will need to avoid eating or drinking in the hours before the test. Your provider may ask you to stop taking any medicines that may affect your test results, especially those that prevent blood clotting. Be sure your provider knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illicit drugs you may use.
Bayhealth is Southern Delaware’s healthcare leader with hospitals in Dover and in Milford. Bayhealth provides a wide range of medical services, including cardiovascular, cancer, orthopaedics and rehabilitation, pediatrics, respiratory care, sleep care, surgical weight loss and women’s services.